SuperCollider responds to incoming MIDI by registering callback functions on MIDI message types
MIDIIn.connect (or MIDIClient.init + MIDIIn.connectAll) opens MIDI input ports. You assign handler functions to MIDIIn.noteOn, .noteOff, .control, .bend, etc. Each function receives port, channel, note number, and velocity (or control number and value). The MIDIFunc / MIDIdef API (modern) adds named, filterable responders that can be removed or replaced. This lets SC respond to hardware controllers, keyboards, and sequencers in real time without polling.
Examples
MIDIIn.connect; MIDIIn.noteOn = { |port, chan, note, vel| Synth.new(\default, [\freq, note.midicps, \amp, 0.2]) };
Assessment
Connect a MIDI keyboard to SC (or use a virtual device). Register a noteOn responder that triggers a custom SynthDef and a noteOff responder that releases it. Test with rapid repeated notes to check polyphony.